|4,9-二甲氧基-7-甲基-5H-呋喃[3,2-g]苯并吡喃-5-酮|CsnPharm

CAS No.: 82-02-0

呋喃并色酮 Catalog No. CSN25434

Synonyms: Amicardine;Corafurone;Methafrone

Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.

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生物活性

描述Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with ultraviolet A. Treatment consisted in topical application of khellin 45 mn before irradiation with EL (excimer lamp) (starting dose 50 mJ/cm2) twice a week for 3 months. The result was a complete regrowth of hair with no recurrence 1 year later^[3]. Khellin stimulated proliferation of Mel-1 melanoma cells and melanocytes at concentrations between 1 nM and 0.5 mM with a peak effect at 0.01 mM. In contrast, khellin inhibited proliferation of fibroblasts over the entire concentration range tested. At concentrations above 0.5 mM, khellin was cytotoxic to both melanocytic cells and fibroblasts. Exposure of khellin-treated cells to single doses of UVA between 150 and 280 mJ/cm2 resulted in an enhanced proliferative effect. Khellin and KUVA also stimulated the melanogenic enzyme activity of pigmented cells, with the most effective treatment being 0.01 mM khellin with 250 mJ cm-2 UVA^[4]. Khellin, a naturally occurring furanochromone from Ammi visnaga, inhibits CYP1A1 enzyme with an IC50 value of 4.02 μM in CYP1A1-overexpressing human HEK293 suspension cells^[5]. Khellin and visnagin were phytotoxic to model species lettuce (Lactuca sativa) and duckweed (Lemna paucicostata), with IC50 values ranging from 110 to 175 μM. These compounds also inhibited the growth and germination of a diverse group of weeds at 0.5 and 1 mM^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8426 mL
- 19.2129 mL
- 38.4258 mL
- 5 mM
- 0.7685 mL
- 3.8426 mL
- 7.6852 mL
- 10 mM
- 0.3843 mL
- 1.9213 mL
- 3.8426 mL

技术信息

CAS号	82-02-0	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H12O5	运输	蓝冰
分子量	260.24	别名	Amicardine;Corafurone;Methafrone;Kelourin;Rykellin;Visammin;Ammispasmin;Ammivisnagen;Gynokhellan;Interkellin;Interkhellin;Amikellin;Ammipuran;Benecardin;Deltoside;Kelicorin;Khelangin;Khellamine;Khellanals;Khellinorm;Medekellin;Visammimix;Viscardan;Visnagalin;Kalangin;Kelincor;Amiptan;Chellin;Coronin;Eskel;Kelicor;Keloid;Lynamine;Mefurina;呋喃并色酮

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呋喃并色酮 Catalog No. CSN25434

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